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KMID : 1120320240100010003
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Osteoporosis and Sarcopenia
2024 Volume.10 No. 1 p.3 ~ p.10
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Asia-Pacific consensus on long-term and sequential therapy for osteoporosis
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Ta-Wei Tai
Hsuan-Yu Chen
Chien-An Shih
Chun-Feng Huang
Eugene McCloskey
Joon-Kiong Lee
Swan Sim Yeap
Ching-Lung Cheung
Natthinee Charatcharoenwitthaya
Unnop Jaisamrarn
Vilai Kuptniratsaikul
Rong-Sen Yang
Sung-Yen Lin
Akira Taguchi
Satoshi Mori
Julie Li-Yu
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Abstract
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Objectives: This study aimed to present the Asia-Pacific consensus on long-term and sequential therapy for osteoporosis, offering evidence-based recommendations for the effective management of this chronic condition.
The primary focus is on achieving optimal fracture prevention through a comprehensive, individualized approach.
Methods: A panel of experts convened to develop consensus statements by synthesizing the current literature and leveraging clinical expertise. The review encompassed long-term anti-osteoporosis medication goals, first-line treatments for individuals at very high fracture risk, and the strategic integration of anabolic and antiresorptive agents in sequential therapy approaches.
Results: The panelists reached a consensus on 12 statements. Key recommendations included advocating for anabolic agents as the first-line treatment for individuals at very high fracture risk and transitioning to antiresorptive agents following the completion of anabolic therapy. Anabolic therapy remains an option for individuals experiencing new fractures or persistent high fracture risk despite antiresorptive treatment. In cases of inadequate response, the consensus recommended considering a switch to more potent medications. The consensus also addressed the management of medication-related complications, proposing alternatives instead of discontinuation of treatment.
Conclusions: This consensus provides a comprehensive, cost-effective strategy for fracture prevention with an emphasis on shared decision-making and the incorporation of country-specific case management systems, such as fracture liaison services. It serves as a valuable guide for healthcare professionals in the Asia-Pacific region, contributing to the ongoing evolution of osteoporosis management.
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KEYWORD
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Sequential therapy, Anti-osteoporosis medication, Fracture prevention, Consensus, Asia?Pacific
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